A pursuit using gene therapy to slow and reverse biological aging in humans.

“To define is to limit.”

― Oscar Wilde, The Picture of Dorian Gray

⚡ The secret to living longer might be to age slower.

Maddalena and Benedetta co-founded Dorian Therapeutics which is bringing to the clinic an innovative solution for age-associated diseases.

Maddalena Adorno graduated magna cum laude and earned her Ph.D. in Biomedicine from the University of Padova, Italy, was a top researcher at Stanford studying stem cells, has spoken at world-renown conferences around the world, hosted a TEDx talk, and is the inventor on several patents in cancer biology, aging and degenerative diseases.

Benedetta di Robilant is also a top researcher at Stanford researching self-renewal and cellular senescence in normal aging and age-related diseases, including cancer, Down syndrome, and Alzheimer’s disease. She holds a Ph.D. in immuno-oncology from the San Raffaele University in Milan, Italy, is the author of several scientific publications in top-tier journals, and is an inventor on U.S. patents.

These two just might hold the secret to slowing the process of aging. They both are researchers in senoblockers, a new class of therapeutics that can rejuvenate cells and tissues. This research is a promising way to address dozens of age-related diseases by treating the process of aging itself.

When someone ages there is a decrease in the activity of stem cells which leads to a reduced regenerative capacity. Additionally, senescent cells (useless damage-causing cells) accumulate in the body and poison entire tissues.

Dorian's Senoblockers act on epigenetic regulators to reverse both processes, reactivating programs of youthfulness and regeneration.

Dorian’s team has accumulated a vast amount of in vitro and in vivo evidence supporting the therapeutic role of senoblockers in Alzheimer’s, osteoporosis, osteoarthritis, diabetes and autoimmune diseases. The small molecules they are developing can be used across multiple diseases, making them a valuable therapeutic tool for the elderly.