- Atria, A. (2019). The Alzheimer’s Disease Clinical Spectrum. Medical Clinics of North America, 103(2), 263-293. doi:10.1016/j.mcna.2018.10.009
- 2020 Alzheimer’s disease and facts and figures. (2020). Alzheimer’s & Dementia, 16(3),
391-460. doi:10.1002/alz.12068
- Mather, M., Jacobsen, L. A., Pollard, K. M. (2015). Aging in the United States.
Population Bulletin, 70(2). Retrieved from
https://www.prb.org/wp-content/uploads/2016/01/aging-us-population-bulletin-1.pdf
- Liu, C.-C., Kanekiyo, T., Xu, H., & Bu, G. (2013). Apolipoprotein E and Alzheimer
disease: risk, mechanisms and therapy. Nature Reviews Neurology, 9(2), 106-118.
doi:10.1038/nrneurol.2012.263
- Zheng, H., Cheng, B., Li, Y., Li, X., Chen, X., & Zhang, Y. (2018). TREM2 in
Alzheimer’s Disease: Microglial Survival and Energy Metabolism. Frontiers in Aging
Neuroscience, 10. doi:10.3389/fnagi.2018.00395
- APP gene - Genetics Home Reference - NIH. (n.d.). Retrieved from
https://ghr.nlm.nih.gov/gene/APP
- Hardy, J. (2002). The Amyloid Hypothesis of Alzheimer’s Disease: Progress and
Problems on the Road to Therapeutics. Science, 297(5580), 353-356.
doi:10.1126/science.1072994
- PSEN1 gene - Genetics Home Reference - NIH. (n.d.). Retrieved from
https://ghr.nlm.nih.gov/gene/PSEN1
- PSEN2 gene - Genetics Home Reference - NIH. (n.d.). Retrieved from
https://ghr.nlm.nih.gov/gene/PSEN2
- APOE gene - Genetics Home Reference - NIH. (n.d.). Retrieved from
https://ghr.nlm.nih.gov/gene/APOE/
- Gratuze, M., Leyns, C.E.G & Holtzman, D.M. (2018). New insights into the role of
TREM2 in Alzheimer’s disease. Molecular Neurodegeneration, 13(1).
doi:10.1186/s13024-018-0298-9
- Zhong, L., & Chen, X.-F. (2019). The Emerging Roles and Therapeutic Potential of
Soluble TREM2 in Alzheimer’s Disease. Frontiers in Aging Neuroscience, 11.
doi:10.3389/fnagi.2019.00328
- Parhizkar, S., Arzberger, T., Brendel, M., Kleinberger, G., Deussing, M., Focke, C.,
Nuscher, B., Xiong, M., Ghasemigharagoz, A., Katzmarski, N., Krasemann, S.,
Lichtenthaler, S. F., Müller, S. A., Colombo, A., Monasor, L. S., Tahirovic, S., Herms, J.,
Willem, M., Pettkus, N.,… Haass, C. (2019). Loss of TREM2 function increases amyloid
seeding but reduces plaque-associated ApoE. Nature Neuroscience.
doi:10.1038/s41593-018-0296-9
- Lee, D. C. Y., Daggett. A., Gu, X., Jiang, L-L., Zhao, Y., Park., C. S., Cooper, Y.,
Ferando, I., Mody, I., Coppola, G., Xu, H., Yang, X. W. (2018). Elevated TREM2 Gene
Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in
Alzheimer’s Disease Models. Neuron, 97(5), 1032-1048.e5.
doi:10.1016/j.neuron.2018.02.002
- Jiang, F., & Doudna, J. A. (2017). CRISPR–Cas9 Structures and Mechanisms. Annual Review of Biophysics, 46(1), 505–529. doi:10.1146/annurev-biophys-062215-010822
- Rees, H. A., Liu, D. R. (2018). Base editing: precision chemistry on the genome and transcriptome of living cells. Nature reviews. Genetics, 19(12), 770-788. doi:10.1038/s41576-018-0059-1
- Rosario, A. M., Cruz, P. E., Ceballos-Diaz, C., Strickland, M. R., Siemienski, Z., Pardo, M., Schob, K. L., Li, A., Aslanidi, G. V., Srivastava, A., Golde, T. E., & Chakrabarty, P. (2016). Microglia-specific targeting by novel capsid-modified AAV6 vectors. Molecular therapy. Methods and clinical development, 3, 16026. doi:10.1038/mtm.2016.26
- Schmidt, S. D., Nixon, R. A., Mathews, P. M. (n.d.). ELISA Method for Measurement of Amyloid-β Levels. Methods in Molecular Biology, 299, 279-298. doi:10.1385/1-59259-874-9:279