In X-linked recessive inheritance only males are affected. An exception to this seen in examinations are patients with Turner's syndrome, who are affected due to only having one X chromosome.

X-linked recessive disorders are transmitted by heterozygote females (carriers) and male-to-male transmission is not seen. Affected males can only have unaffected sons and carrier daughters. Each male child of a heterozygous female carrier has a 50% chance of being affected whilst each female child of a heterozygous female carrier has a 50% chance of being a carrier.

The possibility of an affected father having children with a heterozygous female carrier is generally speaking extremely rare. However, in certain Afro-Caribbean communities G6PD deficiency is relatively common and homozygous females with clinical manifestations of the enzyme defect are seen.

Examples:

X-LINKED RECESSIVE DISEASES

Mnemonics as GRAHAM BELL

G - G6PD deficiency

R - Retinitis pigmentosa

A - Androgen insensitivity

H - Hemophilia A & B

A - Adrenoleucodystrophy

M - Menkes disease

B - Beckers & Duchennes musculardystrophy, Blindness(color blindness)

E - Emery-Dreifuss dystrophy

L - Lesch nyhan syndrome

L - Lowe disease

Kallmann’s syndrome