Paper Name

Variation of the Transmembrane Potential Level as a Basic Mechanism of Mitosis Control (1970)

Link

https://sci-hub.tw/10.1159/000224545

Main objectives

New insight

1970-cell cycle regulators not discovered-G1 arrest known mechanism involving DNA suggested-reversible

Cone(1969a) metabolism connected Em(transmembrane potential) compared b/w G2 and G1 -circuit mediating mitosis initiation-stimulating internal ionic environment thereby changing membrane potential close to a certain state caused a change of state

This paper-expt evidence

• nerve and muscle cells are characterized by their exceptionally high (interphase) transmembrane potential difference Em also low mitotic activity-correlation?
• A primary example is the pronounced decrease in Em level which accompanies the onset of active proliferation in somatic cells during adaptation from in vivo conditions to growth in vitro.

Techniques and usage

Paper Name

Review article The bioelectric code: An ancient computational medium for dynamic control of growth and form

Link

https://oshercenter.org/files/2020/01/Bioelectric-code-review-in-BioSystems.pdf

Key ideas