Compatibility

Compatibility rules for FFP and cryoprecipitate differ from those for red cells; extra care must be taken. Group A (or AB) FFP and plasma are considered "universal". Group O FFP/cryoprecipitate must only be given to group O patients. Where time permits, match components with the patient’s ABO group rather than relying on group A/AB FFP.

Patient’s blood group	Choice priority	FFP	Cryo
O	1st	O	O
	2nd	A	A
	3rd	B	B
A	1st	A	A
	2nd	AB	B*
	3rd	B*	AB
B	1st	B	B
	2nd	AB	A*
	3rd	A*	AB
AB	1st	AB	AB
	2nd	A*	A*
	3rd	B*	B*

= Only suitable for emergency use and if unit is tested and found to be negative for high titre ABO antibodies

Codes (F = FFP, C = Cryoprecipitate)

Storage of FFP and Cryo

Fresh Frozen Plasma and Cryoprecipitate are stored at -25°C for up to 3 years. Once a request is received the component is thawed at 37°C and allow 15-30 minutes for this procedure.
These components should be transfused as soon as possible and must be completed within 4 hours of removal from Temperature Controlled Storage.
If unused, these components must be returned to the transfusion laboratory. Although these components cannot be re-frozen, they may be issued for another patient within a defined period of time. Please check with HTL.
Octaplas is a solvent detergent (SD) treated FFP pharmaceutically manufactured from pooled donor plasma, indicated in specific clinical situations. Storage, handling and use is generally the same as for FFP - check with your HTL. Further information can be found at Guidelines for the Blood Transfusion Services(opens in a new tab).

Adults

Typical transfusion volumes:

FFP
Dose	15‑20mL/kg body weight, often equivalent to 4 units in adults. Lower doses have little therapeutic benefit and still carry risks of transfusion.