Streptococci

Group A strep (Strep. pyogenes)

Toxins produced:

Streptolysin O --> hemolysis (Oxygen labile)

Streptolysin S --> hemolysis (oxygen Stable)

Erythrogenic/pyrogenic toxins --> skin rash (erythro-) and fever (pyro-) of scarlet fever

streptokinase

DNAase

SpeA - superantigen (TSLS)

SpeB - protease (Necrotizing fascitis)

SpeC - superantigen (TSLS)

TSLS - Toxic Shock syndrome like symptom/syndrome

Hyaluronic acid => non-immunogenic

M-protein = anti-phagocytic, highly immunogenic

associated with rheumatic fever,

(M protein mimics myosin in the heart --> attack wrongly)

M12 protein is associated with glomerulonephritis

(Type III hypersensitivity - immune complex)

Group B strep (Streptococcus agalactiae)