Update Route Table when...

You want to control where traffic goes (direction/path).

Scenario Route Table Change
Private EC2 needs internet via NAT Add 0.0.0.0/0 → NAT Gateway in private subnet RT
Public EC2 needs internet Add 0.0.0.0/0 → IGW in public subnet RT
Two VPCs need to talk (VPC Peering) Add the other VPC's CIDR → peering connection
On-premise network via VPN Add on-prem CIDR → VPN Gateway

Trigger thought: "Where should this traffic be sent?"


Update Security Group when...

You want to control whether traffic is allowed at an instance.

Scenario SG Change
Allow SSH to a bastion host Inbound SSH from your IP
Allow your app to talk to RDS Inbound 3306 from app's SG
Block all traffic except HTTPS Remove all inbound except port 443

Trigger thought: "Should this instance accept or reject this traffic?"