Antisynthetase syndrome

Antisynthetase syndrome is characterized by interstitial lung disease, myositis, Raynaud phenomenon, nonerosive inflammatory arthritis, constitutional findings such as low-grade fever, and mechanic's hands; anti-aminoacyl-tRNA synthetases antibodies, such as anti–Jo-1, are highly suggestive of the diagnosis.

Fibromyalgia

Relapsing Polychondritis

idiopathic disorder characterized by recurrent inflammation of cartilaginous structures and other internal organs

multiple organs may be involved in this disorder but involvement of ear is the most frequent

Unilateral or bilateral inflammation of auricle occurs with sparing of the non-cartilaginous ear lobules and produces marked pain and tenderness.

Skin of the auricle becomes violaceous or erythematous

There may be repeated episodes producing deformity of the auricle

?autoimmune response targeting cartilate-containing structures

So, other than auricular disease, nasal cartilage disease, laryngotracheobronchial disease may also occur

Chronic inflammation -> luminal narrowing and peritracheal inflammation --> causes destruction of the supportive matrix around the tracheobronchial tree, and collapse on expiration is exaggerated

On PFTs/ flow loops, decreased expiratory flow can be seen

Other organs involved include eyes, joints, vascular system, skin and nervous system

Eye involvement is usually in the form of conjunctivitis, episcleritis, or scleritis