Lifetime risk of developing
It is the most common cancer in men and the second most common cause of male cancer death (in the UK)
The incidence increases with age, 1/2 of the cases occur in men over the age of 75
Risk Factors
Family history
Having a relative who developed the disease before the age of 60 is the significant risk factor (not cigarette smoking, aniline dye exposure, etc.)
A father or brother with the disease more than doubles an individual’s risk compared to the general population; having two or more first degree relatives quadruples the risk.
Ethnicity
Black African and Black Caribbean men are three times more likely to develop prostate cancer than white men of the same age in the UK, and on average are 3-5 years younger at presentation. Asian men have a lower risk compared to other groups.
Diet
May be important, with foods containing lycopene and selenium believed to reduce prostate cancer risk. Tomatoes are good sources of lycopene, while selenium is found in some plant-based foods such as Brazil nuts and in seafood.
Incidence and mortality are significantly higher in men who are overweight or obese.
PSA - a ****glycoprotein produced only in the cytoplasm of prostate cells