Dopamine antagonist
Lower incidence of oculogyric crisis compared to metoclopramide
Antihistaminergic
up to 50mg TDS
1-2 h before journey for motion sickness
D2 dopamine receptor antagonist
Adverse effect: Oculogyric crisis
Rx: IV Benzatropine (effects within five minutes)
Procyclidine hydrochloride (for drug-induced extrapyramidal symptoms (but not tardive dyskinesia)
PO 2.5 mg 3 times a day, then increased in steps of 2.5 mg daily as required, usual maintenance 10–30 mg daily in 2–3 divided doses.
