Multiple Sclerosis

more common in white women who live in colder climates

Better Prognosis factor

• optic neuritis or isolated sensory symptom
• Initial relapsing-remitting course
• long interval to second relapse
• no disability after 5 years
• Normal Initial MRI scan
• female gender
• younger age at onset
• complete recovery from 1st neurological episode

Poor Prognostic signs:

1. Older Male
2. Motor signs at onset
3. many relapses early on (high relapse rate in first 2-5years)
4. many MRI lesions/ abnormal Initial MRI scan with large lesion load
5. axonal loss
6. Substantial disability after 5years