Hepatic Adenoma
benign epithelial tumors that usually arise as a solitary mass in the right hepatic lobe
predominant in young, middle-aged women with lengthy history of OCPs use
also associated with anabolic androgen use, glycogen storage disease, pregnancy, and DM
Histology: sheets of enlarged adenoma cells that contain glycogen and lipid; nuclei are regular but small
normal hepatic architecture is absent (with septa, portal tracts, and bile ductules missing)
Risk of rupture and intraperitoneal hemorrhage is high, esp. during pregnancy
Thus, biopsy is contraindicated
LFTs may be normal
ALPase and GGT are most commonly elevated in those patients with intratumoral bleeding or multiple adenomas
Alpha-fetoprotein is normal unless malignant transformation of the tumor has occurred, which happens in 8-13% among all patients with hepatic adenomas.
Hepatocellular Carcinoma (HCC)
Risk factors: