Leukemoid reaction
Profound leukocytosis > 50
characterized by a significant increase in early neutrophil precursors in the peripheral blood
it is the response of normal bone marrow to cytokine release by lymphocytes, macrophages and other cells in response to infection or trauma
marked "left shift", increased numbers of band forms and sometimes even myelocytes and metamyelocytes in peripheral film.
Proliferation of all NORMAL myeloid elements is observed in bone marrow, whereas immature elements predominate in acute leukemia
low or absent CD 16 --> reduce expresion of Fc receptors --> cannot function as well as mature ones
high Leukocyte alkaline phosphatase (whereas Leukemia has low LAP)