Therapeutic IVIG

Uses

• primary and secondary immunodeficiency
• idiopathic thrombocytopenic purpura
• myasthenia gravis
• Guillain-Barre syndrome
• Kawasaki disease
• toxic epidermal necrolysis
• pneumonitis induced by CMV following transplantation
• low serum IgG levels following haematopoietic stem cell transplant for malignancy
• dermatomyositis
• chronic inflammatory demyelinating polyradiculopathy

Basics

• formed from large pool of donors (e.g. 5,000)
• IgG molecules with a subclass distribution similar to that of normal blood
• half-life of 3 weeks