Hypercalcemia

most common cause of hypercalcemia -> primary hyperparathyroidism

Granulomatous diseases such as sarcoidosis, TB, berylliosis, histoplasmosis and coccidioidomycosis are all associated with hypercalcemia

Rare causes - vit. D intoxication, thiazide, lithium, Paget, prolonged immobilization

also hyperthyroidism (due to partial effect of thyroid hormone on osteoclasts)

Clinical features

• Bone Pain
• Muscular weakness
• Anoexia
• Nausea and vomiting
• Constipation
• Peptic ulceration
• Pancreatitis
• Psychic moans
• ECG changes shortening of QT