Hemophilia A & B

X-linked recessive; hence almost exclusively in males7

factor VIII = hemophilia A

factor IX = hemophilia B

Hemophilic arthropathy, a late complication that occurs in both types of hemophilia and is a significant source of morbidity, is thought to be caused by iron/hemosiderin deposition leading to synovitis and fibrosis within the joint.

Tx

Hemophilia A

Minor bleed = desmopressin (releases endogenous factor) plus aminocaproic acid or tranexamic acid (minimize fibrinolysis)

Cryoprecipitate is NOT used.

Major bleed - factor VIII

Hemophilia B

factor IX concentrates for both major and minor bleeding