Hemoglobin Oxygen Dissociation Curve

P50% = partial pressure of oxygen at which hemoglobin is 50% saturated.

High-oxygen-affinity hemoglobins have a decreased P50 that is respresented by a leftward shift of the oxygen-dissociation curve.

High-oxygen-affinity hemoglobins have reduced ability to release oxygen within the peripheral tissues, leading to renal hypoxia, increased erythropoietin synthesis, and compensatory erythrosis.