


These gastric polyps were positive for CD34+ blasts, consistent with gastric myeloid sarcoma, a rare condition characterised by the invasion of the GI tract by myeloid blasts. This is most commonly seen with AML or myeloproliferative conditions. The patient actually had a history of chronic myelomonocytic leukaemia with transformation to myelofibrosis.
Treatment usually involves chemotherapy, targeted therapy or bone marrow transplantation. This patient was managed palliatively.
Moral of the story - if in doubt with gastric polyps, biopsy or better still remove one of them for histopath. These could easily have been diagnosed as hyperplastic gastric polyps.
The BSG 2019 guidelines recommend that all gastric polyps other than fundic gland polyps should be biopsied for histopathological assesssment.
https://gut.bmj.com/content/68/9/1545
Guidelines on Gastric Ca