Endometrial Hyperplasia
Risk factors
chronic stimulation from estrogen (e.g, obesity, anovulation) without the balancing effect of progesterone
Dx
Biopsy and Histology
Simple or Complex
with or without nuclear atypia
Tx
No atypia = low risk for concurrent malignancy
treat with potent progestin
repeat biopsy after 3 months to assess response
All reproductive age women with chronic anovulation PCOS) are at high risk of endometrial carcinoma.
Give progestins to prevent endometrial hyperplasia and cancer.
Endometrial Carcinoma
can follow 2 pathways;