Drug-induced liver disease is generally divided into hepatocellular, cholestatic or mixed. There is however considerable overlap, with some drugs causing a range of changes to the liver.

The following drugs tend to cause a hepatocellular picture:

• paracetamol
• sodium valproate, phenytoin
• MAOIs
• halothane
• anti-tuberculosis: isoniazid, rifampicin, pyrazinamide
• statins
• alcohol
• amiodarone
• methyldopa
• nitrofurantoin

The following drugs tend to cause cholestasis (+/- hepatitis):

• combined oral contraceptive pill
• antibiotics: flucloxacillin, co-amoxiclav, erythromycin*
• anabolic steroids, testosterones
• phenothiazines: chlorpromazine, prochlorperazine
• sulphonylureas