Interferons

Def

Interleukins

"Hot T-Bone stEAK"

IL-1: fever (hot) = pyrogen

IL-2: T cell activator

IL-3: Bone marrow stimulant

IL-4: IgE class switching; promotes Th0 to Th2

IL-5: IgA class switch; E(5th alphabet)Eosinophil differentiation (Five - fight differently)

IL-6: aKute-phase protein promotion

IL1 (Anakinra) + TNF-alpha (infliximab, adalimumab, etanercept)

Fever and cachexia

IL-1 and TNF-alpha --> induce expression of E-selectin from endothelial cells and CAMs

induces fever by stimulating COX --> PGE2

IL-2 => T-Cell Activation

remember "2-Cell Activation"