There are two primary guides in the community, both of which are somewhat outdated - but still useful

Zenthrow's Beginner Guide (2017)

Neon's Advanced Guide (2019)

Setting Up the Save to Skip Cutscenes:

https://www.youtube.com/watch?v=h2EsqdIwTQc&feature=youtu.be

This is a necessary step - the cutscenes TAKE TIME - less cutscenes = better time, keep that in mind.

This DOES NOT count as part of the time used during the run.