Lambert-Eaton myasthenic syndrome
associated with small cell lung cancer (also breast and ovarian)
antibody directed against pre-synaptic voltage gated calcium channel in the peripheral nervous system
can also occur independently as autoimmune disorder
Acetylcholine receptor Ab: Myasthenia gravis (90%) - post-synaptic
anti-voltage-gated K+channel Ab: limbic encephalitis
Anti-aquaporin 4: Neuromyelitis optica (Devic's disease)
Anti-Hu
associated with small cell lung carcinoma and neuroblastomas
sensory neuropathy - may be painful
cerebellar syndrome
encephalomyelitis
Anti-Yo
associated with ovarian and breast cancer
cerebellar syndrome
Anti-GAD antibody
associated with breast, colorectal and small cell lung carcinoma
stiff person's syndrome or diffuse hypertonia
Anti-Ri