Antimycobacterial Drugs

Isonazid (INH)

inhibits the synthesis of mycolic acids

solo prophylaxis against TB

neurotoxic (prevents with B6) and hepatotoxic

Rifampin

"R"s

RNA polymerase inhibitor

Revs up microsomal P450

Red-orange body fluids

Rapid Resistance if used alone

Relatives/close contacts of meningitis (N. meningitidis; H. influenzae type B) for prophylaxis

Pyrazinamide

Ethambutol

decreases carbohydrate polymerization of mycobacterium cell wall by blocking arabinosyl-transferase

S.E. optic neuropathy -> red-green color blindness