Antibiotics targeting Protein synthesis

"Buy AT 30, CCELL at 50"

• 30S inhibitors
  • Aminoglycosides
  • Tetracyclines
• 50S inhibitors
  • Chloramphenicol
  • Clindamycin
  • Erythromycin, macrolides
  • Lincomycin
  • Linezolid (23S subunit of 50S)

Linezolid

MOA: binds 23S RNA and interacts with the bacterial initiation complex

Uses:

MRSA

VRE (vancomycin resistant enterococci)

Tetracyclines

Tetracycline, doxycycline, demeclocycline, minocycline

binds to the 30S and prevents attachment of aminoacyl-tRNA

bacteriostatic

limited CNS penetration

Doxycycline is fecally eliminated

Uses: "VACUUM THe BedRoom"

• Vibrio cholerae
• Acne
• Chlamydia
• Ureaplasma urealyticum