Side Effects

DOC for common infections

Tetracyclines

MOA

Inhibits cell wall formation

• peptidoglycan cross-linking: penicillins, cephalosporins, carbopenems
• peptidoglycan synthesis: glycopeptides (e.g. vancomycin)

Inhibits protein synthesis (by acting on the ribosome)

• 50S subunit: macrolides, chloramphenicol, clindamycin, linezolid, streptogrammins
• 30S subunit: aminoglycosides, tetracyclines

Inhibits DNA synthesis

• quinolones (e.g. ciprofloxacin)

Damages DNA

• metronidazole

Inhibits folic acid formation

• sulphonamides
• trimethoprim

Inhibits RNA synthesis