• NTIBO: AI-Driven Drug Discovery for Previously Untargetable Proteins
• Focused upon: Metabolic & Age-Related Disorders
• IBM Partner Plus
• Arrow-Funded IBM TechXchange Participant
• 4 patents filed (5th in development)

Problem

30-50% of disease proteins lack stable structures

• SIRT6 - key metabolic regulator (undruggable until now)
• Inflammatory IDRs driving chronic disease
• Age-related protein dysfunction

Solution

Patented platform reveals hidden drug sites in undruggable proteins. Platform benchmarked on TDP-43 & a-synuclein; poised for SIRT6 validation

How It Works : Complementary proteases reveal hidden drug sites

Elastase reveals hydrophobic cores where drugs can bind